Evolutionarily conserved genes preferentially accumulate introns
نویسندگان
چکیده
منابع مشابه
hv1 is an evolutionarily conserved H2A variant that is preferentially associated with active genes.
Polyclonal antibodies to the Tetrahymena macronuclear-specific histone variant hv1 cross-react with histone-like molecules from yeast, wheat, and mouse. A novel purification scheme has allowed isolation of sufficient hv1 to enable determination of the sequence of 61 amino-terminal residues as well as 27 additional internal residues. These data clearly demonstrate that hv1 shares a number of con...
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Evolutionarily conserved mechanisms that control aging are predicted to have prereproductive functions in order to be subject to natural selection. Genes that are essential for growth and development are highly conserved in evolution, but their role in longevity has not previously been assessed. We screened 2,700 genes essential for Caenorhabditis elegans development and identified 64 genes tha...
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According to the length distribution of human introns, there is a large population of short introns with a threshold of 65 nucleotides (nt) and a peak at 85 nt. Using human genome and transcriptome databases, we investigated the introns shorter than 66 nt, termed ultra-short introns, the identities of which are scarcely known. Here, we provide for the first time a list of bona fide human ultra-...
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The homeodomain is a DNA binding domain about 60 amino acids in length that occurs in many developmental regulatory proteins. Based on their degree of relatedness, homeodomain sequences have been grouped into 10 different families plus some unclassified sequences (1). Using a set of degenerate oligonucleotides (hom3 and en5) designed to anneal to homeoboxes, we employed the polymerase chain rea...
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After decades of ignominy as ‘junk’, ‘parasite’ or ‘selfish’, noncoding deoxyribonucleic acid (DNA) present in introns and intergenic regions has recently been recognized as symbolizing a rich fossil record of DNA sequences subject to variation and conservation throughout evolution. In addition to clusters of evolutionarily conserved genes in close proximity to one another, human chromosomes al...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2007
ISSN: 1088-9051
DOI: 10.1101/gr.5978207